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Background  Systemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle ( RV ) is unknown.    Methods and Results  The associations between systemic arterial measures (total arterial compliance [ TAC ], systemic vascular resistance [ SVR ], and aortic augmentation index [ AI ]) and  RV  morphology (mass, end‐systolic [ RVESV ] and end‐diastolic volume [ RVEDV ], and ejection fraction [ RVEF ]) were examined using data from the Multi‐Ethnic Study of Atherosclerosis. All analyses were adjusted for anthropometric, demographic, and clinical variables and the corresponding left ventricular parameter. A total of 3842 subjects without clinical cardiovascular disease were included with a mean age of 61 years, 48% male, 39% non‐Hispanic white, 25% Chinese‐American, 23% Hispanic, and 13% black. RV measures were within normal range for age and sex. A 1‐mL/mm Hg decrease in  TAC  was associated with 3.9‐mL smaller  RVESV , 7.6‐mL smaller  RVEDV , and 2.4‐g lower  RV  mass. A 5‐Wood‐unit increase in  SVR  was associated with 0.6‐mL decrease in  RVESV , 1.7‐mL decrease in  RVEDV , and 0.4‐g decrease in  RV  mass. A 1% increase in  AI  was associated with 0.2‐mL decrease in  RVEDV . We found significant effect modification by age, sex, and race for some of these relationships, with males, whites, and younger individuals having greater decreases in  RV  volumes and mass.    Conclusions  Markers of increased systemic arterial load were associated with smaller  RV  volumes and lower  RV  mass in a population of adults without clinical cardiovascular disease.

journal of the american heart association

Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis ( MESA )‐Right Ventricle Study