Open AccessMetabolic Signature of Remote Ischemic Preconditioning Involving a Cocktail of Amino Acids and Biogenic Amines
Author(s) -
Chao de la Barca Juan Manuel,
Bakhta Oussama,
Kalakech Hussein,
Simard Gilles,
Tamareille Sophie,
Catros Véronique,
Callebert Jacques,
Gadras Cédric,
Tessier Lydie,
Reynier Pascal,
Prunier Fabrice,
MirebeauPrunier Delphine
Publication year - 2016
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.116.003891
Subject(s) - medicine , ischemic preconditioning , amino acid , cardiology , pharmacology , ischemia , biochemistry , chemistry
Remote ischemic preconditioning (RIPC) is an attractive therapeutic procedure for protecting the heart against ischemia/reperfusion injury. Despite evidence of humoral mediators transported through the circulation playing a critical role, their actual identities so far remain unknown. We sought to identify plasmatic RIPC-induced metabolites that may play a role.