Open AccessPhosphodiesterase Inhibitor‐Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation
Author(s) -
Mills Kimberly I.,
Kaza Aditya K.,
Walsh Brian K.,
Bond Hilary C.,
Ford Mackenzie,
Wypij David,
Thiagarajan Ravi R.,
Almodovar Melvin C.,
Quiz Luis G.,
Baird Christopher W.,
Emani Sitaram E.,
Pigula Frank A.,
DiNardo James A.,
Kheir John N.
Publication year - 2016
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.116.003554
Subject(s) - medicine , milrinone , extracorporeal membrane oxygenation , anesthesia , vascular resistance , cardiology , vasodilation , pulmonary artery , oxygenation , hemodynamics
Systemic vasodilation using α-receptor blockade has been shown to decrease the incidence of postoperative cardiac arrest following stage 1 palliation (S1P), primarily when utilizing the modified Blalock-Taussig shunt. We studied the effects of a protocol in which milrinone was primarily used to lower systemic vascular resistance (SVR) following S1P using the right ventricular to pulmonary artery shunt, measuring its effects on oxygen delivery (DO 2 ) profiles and clinical outcomes. We also correlated Fick-based assessments of DO 2 with commonly used surrogate measures.