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Background  Adults <50 years old, with diabetes mellitus, or a history of stroke were not enrolled in the Systolic Blood Pressure Intervention Trial ( SPRINT ). Estimating the size and characteristics of these excluded groups who meet the other  SPRINT  eligibility criteria may provide information on the potential impact of providers extending the  SPRINT  findings to these populations.    Methods and Results  We analyzed the National Health and Nutrition Examination Survey 2003–2012 (n=25 076) to estimate the percentage and characteristics of  US  adults ≥20 years in 3 populations (age <50 years, diabetes mellitus, or history of stroke) excluded from  SPRINT  who otherwise meet the trial eligibility criteria: age ≥50 years, systolic blood pressure ( SBP ) 130–180 mm Hg, high cardiovascular disease risk, and not having trial exclusion criteria. Overall, 1.0% (95%  CI  0.8–1.3) of  US  adults age <50 years, 25.4% (95%  CI  23.4–27.6) with diabetes mellitus, and 19.0% (95%  CI  16.0–22.4) with history of stroke met the other  SPRINT  eligibility criteria. Among  US  adults with  SBP  ≥130 mm Hg, other  SPRINT  eligibility criteria were met by 7.5% (95%  CI  6.1–9.2) of those age <50 years, 32.9% (95%  CI  30.5–35.4) with diabetes mellitus, and 23.0% (95%  CI  19.4–27.0) with history of stroke. Among  US  adults meeting the other  SPRINT  eligibility criteria, antihypertensive medication was being taken by 31.0% (95%  CI  23.9–41.3) of those <50 years, 63.0% (95%  CI  58.2–67.6) with diabetes mellitus, and 68.9% (95%  CI  59.4–77.1) with a history of stroke.    Conclusions  A substantial percentage of  US  adults with diabetes mellitus or history of stroke and a small percentage <50 years old meet the other  SPRINT  eligibility criteria.

journal of the american heart association

Prevalence of Eligibility Criteria for the Systolic Blood Pressure Intervention Trial in  US  Adults Among Excluded Groups: Age &lt;50 Years, Diabetes Mellitus, or a History of Stroke