Open AccessMending a Broken Heart: The Role of Sarcospan in Duchenne Muscular Dystrophy–Associated Cardiomyopathy
Author(s) -
Vander Heide Richard S.
Publication year - 2015
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.115.002928
Subject(s) - medicine , duchenne muscular dystrophy , cardiomyopathy , cardiology , muscular dystrophy , heart failure , dystrophin , physical therapy
Duchenne muscular dystrophy (DMD) is the most severe and most common form of X‐linked muscular diseases. It has been known for over 25 years that DMD is caused by a gene mutation leading to the near total absence of functional dystrophin protein. Transcription of the gene is controlled by 3