English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background  Although clear evidence shows that chronic kidney disease is a predictor of cardiovascular events, death, and accelerated coronary artery disease ( CAD ) progression, it remains unknown whether  CAD  is a predictor of progression of chronic kidney disease to end‐stage renal disease. We sought to assess whether  CAD  adds prognostic information to established predictors of progression to dialysis in patients with chronic kidney disease, diabetes, and anemia.    Methods and Results  Using the previously described Trial to Reduce Cardiovascular Events With Aranesp Therapy ( TREAT ) population, we compared baseline characteristics of patients with and without  CAD . Cox proportional hazards models were used to assess the association between  CAD  and the outcomes of end‐stage renal disease and the composite of death or end‐stage renal disease. Of the 4038 patients, 1791 had a history of known  CAD . These patients were older (mean age 70 versus 65 years,  P <0.001) and more likely to have other cardiovascular disease.  CAD  patients were less likely to have marked proteinuria (29% versus 39%,  P <0.001), but there was no significant difference in estimated glomerular filtration rate between the 2 groups. After adjusting for age, sex, race, estimated glomerular filtration rate, proteinuria, treatment group, and 14 other renal risk factors, patients with  CAD  were significantly more likely to progress to end‐stage renal disease (adjusted hazard ratio 1.20 [95%  CI  1.01–1.42],  P =0.04) and to have the composite of death or end‐stage renal disease (adjusted hazard ratio 1.15 [95%  CI  1.01–1.30],  P =0.03).    Conclusions  In patients with chronic kidney disease, diabetes, and anemia, a history of  CAD  is an independent predictor of progression to dialysis. In patients with diabetic nephropathy, a history of  CAD  contributes important prognostic information to traditional risk factors for worsening renal disease.

journal of the american heart association

Coronary Artery Disease Is a Predictor of Progression to Dialysis in Patients With Chronic Kidney Disease, Type 2 Diabetes Mellitus, and Anemia: An Analysis of the Trial to Reduce Cardiovascular Events With Aranesp Therapy ( TREAT )