English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background  Conflicting data exist about the cardiovascular risk of metabolically healthy obese persons. The prognostic value of C‐reactive protein ( CRP ) in this intriguing group is unknown. We assessed the association between  CRP  levels and the risk of coronary heart disease ( CHD ) in metabolically healthy persons with abdominal obesity.    Methods and Results  In the European Prospective Investigation of Cancer–Norfolk prospective cohort,  CRP  levels and information on metabolic syndrome criteria were available for 7279 participants, of whom 825 (11%) developed  CHD  during a follow‐up period of 10.9±1.8 years. There was a trend toward a higher multivariable‐adjusted hazard ratio for  CHD  in metabolically healthy obese participants with  CRP  levels >2 mg/L compared with <2 mg/L (hazard ratio 1.59, 95%  CI  0.97–2.62,  P =0.066). Metabolically unhealthy obese participants had significantly higher  CHD  risk compared with metabolically healthy obese participants with  CRP  levels <2 mg/L (hazard ratio 1.88, 95%  CI  1.20–2.94,  P =0.006). Most important, we found that the risk of  CHD  among metabolically healthy obese persons with  CRP  levels <2 mg/L was comparable to that of metabolically healthy nonobese persons (hazard ratio 0.91, 95%  CI  0.60–1.39,  P =0.674).    Conclusions  Among metabolically healthy obese persons, low  CRP  levels were associated with a  CHD  risk comparable to that of metabolically healthy nonobese persons.  CRP  appears to be an easy and widely available method for identifying a low‐risk subpopulation among metabolically healthy obese persons.

journal of the american heart association

C‐Reactive Protein Identifies Low‐Risk Metabolically Healthy Obese Persons: The European Prospective Investigation of Cancer–Norfolk Prospective Population Study