English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Open

Presents the pdf analysis as premium feature

PDF Analysis

Insights

Presents the summarisation as premium feature

Summarisation

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Background  Beyond their resting values, exercise responses in blood pressure ( BP ) and heart rate ( HR ) may add prognostic information for cardiovascular disease ( CVD ). In cross‐sectional studies, exercise  BP  and  HR  responses correlate with  CVD  risk factors; however, it is unclear which factors influence longitudinal changes in exercise responses over time, which is important for our understanding of the development of  CVD .    Methods and Results  We assessed  BP  and  HR  responses to low‐level exercise tests (6‐minute Bruce protocol) in 1231 Framingham Offspring participants (55% women) who underwent a routine treadmill test in 1979–1983 (baseline; mean age 39±8 years) that was repeated in 1998–2001 (follow‐up; mean age 58±8 years). Adjusting for baseline exercise responses, we related the follow‐up exercise responses to baseline  CVD  risk factors and to their changes between examinations. Compared with men, women had greater rise in exercise systolic (S) BP  and  HR  at 20‐year follow‐up (both  P <0.005). Baseline blood lipid levels, resting  SBP  and  HR , and smoking status were associated with greater exercise  SBP  at follow‐up (all  P <0.05). Weight gain across examinations was associated with higher exercise  SBP  and  HR  at follow‐up (both  P <0.0001). Smoking cessation was associated with a 53% reduced risk of attaining the highest quartile of exercise  SBP  (≥180 mm Hg) at follow‐up ( P <0.05).    Conclusion  An adverse  CVD  risk factor profile in young adults and its worsening over time were associated with higher  SBP  and  HR  responses to low‐level exercise in midlife. Maintaining or adopting a healthy risk factor profile may favorably impact the exercise responses over time.

Submaximal Exercise Systolic Blood Pressure and Heart Rate at 20 Years of Follow‐up: Correlates in the Framingham Heart Study