Open AccessComprehensive Assessment of Coronary Plaque Progression With Advanced Intravascular Imaging, Physiological Measures, and Wall Shear Stress: A Pilot Double‐Blinded Randomized Controlled Clinical Trial of Nebivolol Versus Atenolol in Nonobstructive Coronary Artery Disease
Author(s) -
Hung Olivia Y.,
Molony David,
Corban Michel T.,
RasoulArzrumly Emad,
Maynard Charles,
Eshtehardi Parham,
Dhawan Saurabh,
Timmins Lucas H.,
Piccinelli Marina,
Ahn Sung Gyun,
Gogas Bill D.,
McDaniel Michael C.,
Quyyumi Arshed A.,
Giddens Don P.,
Samady Habib
Publication year - 2016
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.115.002764
Subject(s) - nebivolol , medicine , intravascular ultrasound , cardiology , atenolol , coronary artery disease , endothelial dysfunction , lumen (anatomy) , blood pressure
We hypothesized that nebivolol, a β-blocker with nitric oxide-mediated activity, compared with atenolol, a β-blocker without such activity, would decrease oxidative stress and improve the effects of endothelial dysfunction and wall shear stress (WSS), thereby reducing atherosclerosis progression and vulnerability in patients with nonobstructive coronary artery disease.