Open AccessPreserved Autonomic Cardiovascular Regulation With Cardiac Pacemaker Inhibition: A Crossover Trial Using High‐Fidelity Cardiovascular Phenotyping
Author(s) -
Heusser Karsten,
Tank Jens,
Brinkmann Julia,
Schroeder Christoph,
May Marcus,
Großhennig Anika,
Wenzel Daniela,
Diedrich André,
Sweep Fred C. G. J.,
Mehling Heidrun,
Luft Friedrich C.,
Jordan Jens
Publication year - 2016
Publication title -
journal of the american heart association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.494
H-Index - 85
ISSN - 2047-9980
DOI - 10.1161/jaha.115.002674
Subject(s) - ivabradine , baroreflex , medicine , heart rate , bradycardia , microneurography , blood pressure , cardiology , anesthesia , tachycardia
Sympathetic and parasympathetic influences on heart rate (HR), which are governed by baroreflex mechanisms, are integrated at the cardiac sinus node through hyperpolarization-activated cyclic nucleotide-gated channels (HCN4). We hypothesized that HCN4 blockade with ivabradine selectively attenuates HR and baroreflex HR regulation, leaving baroreflex control of muscle sympathetic nerve activity intact.