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Background  The long‐term effects of transient hypothermia by the non‐invasive ThermoSuit apparatus on myocardial infarct ( MI ) scar size, left ventricular ( LV ) remodeling, and  LV  function were assessed in rat  MI  model.    Methods and Results  Rats were randomized to normothermic or hypothermic groups (n=14 in each group) and subjected to 30 minutes coronary artery occlusion and 6 weeks of reperfusion. For hypothermia therapy, rats were placed into the ThermoSuit apparatus at 2 minutes after the onset of coronary artery occlusion, were taken out of the apparatus when the core body temperature reached 32°C (in ≈8 minutes), and were then allowed to rewarm. After 6 weeks of recovery, rats treated with hypothermia demonstrated markedly reduced scar size (expressed as % of left ventricular area: hypothermia, 6.5±1.1%; normothermia, 19.4±1.7%;  P =1.3×10 −6 ); and thicker anterior  LV  wall (hypothermia, 1.57±0.09 mm; normothermia, 1.07±0.05 mm;  P =3.4×10 −5 ); decreased postmortem left ventricular volume (hypothermia, 0.45±0.04 mL; normothermia, 0.6±0.03 mL;  P =0.028); and better  LV  fractional shortening by echocardiography (hypothermia, 37.2±2.8%; normothermia, 18.9±2.3%;  P =0.0002) and  LV  ejection fraction by  LV  contrast ventriculography (hypothermia, 66.8±2.3%; normothermia, 56.0±2.0%;  P =0.0014).    Conclusions  Rapid, transient non‐invasive surface cooling with the ThermoSuit apparatus in the acute phase of  MI  decreased scar size by 66.5%, attenuated adverse post‐infarct left ventricular dilation and remodeling, and improved cardiac function in the chronic phase of experimental  MI .

journal of the american heart association

Rapid Surface Cooling by ThermoSuit System Dramatically Reduces Scar Size, Prevents Post‐Infarction Adverse Left Ventricular Remodeling, and Improves Cardiac Function in Rats