Open AccessSuccessful Treatment of Primary Cutaneous Anaplastic Large Cell Lymphoma with Denileukin Diftitox
Author(s) -
Amagai Mayuko,
Furudate Sadanori,
Ohuchi Kentaro,
Takahashi Toshiya,
Yamazaki Emi,
Chiba Hiromu,
Asano Yoshihide,
Fujimura Taku
Publication year - 2022
Publication title -
case reports in oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 19
ISSN - 1662-6575
DOI - 10.1159/000526312
Subject(s) - case report
Primary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare variant of cutaneous T cell lymphoma (CTCL) characterized by CD30-expressing large atypical cells with kidney-shaped nuclei called hallmark cells. Since PCALCL is a rare variant of CTCL, the treatment of PCALCL is still controversial. In this report, a case of PCALCL successfully treated with denileukin diftitox as second-line therapy is described. Interestingly, the administration of denileukin diftitox decreased CD8+ T cells, CD25+ cells, granulysin-bearing lymphocytes, and CD163+ macrophages. The present case suggests that denileukin diftitox might induce an anti-lymphoma effect as well as modulate the tumor microenvironment.