Rapid Development of Syringocystadenocarcinoma Papilliferum in an Immunosuppressed Liver Transplant Recipient

Syringocystadenocarcinoma papilliferum (SCACP) is a rare cutaneous adnexal neoplasm. To the best of our knowledge, fewer than 50 cases have been described in the literature. We describe the first reported case of an SCACP in an immunocompromised patient. We report the development of an SCACP over 3 months in a 77-year-old organ transplant recipient undergoing regular dermatological follow-up. The lesion was excised with clear margins with Mohs micrographic surgery. This lesion’s rapid development and small size contrasts with the predominantly slow-growing, larger lesions described in immunocompetent patients. Lastly, this case further highlights the importance of close dermatological follow-up of immunosuppressed patients.