Open AccessSevere Vulvar and Perianal Crohn’s Disease: A Case Report and Review of the Literature
Author(s) -
Le Cosquer Guillaume,
Barranca Alexis,
Lapotre Louise,
Casassa Eline,
Chaput Benoit,
Ciron Jonathan,
Buscail Louis,
Paul Carle,
Gilletta Cyrielle
Publication year - 2022
Publication title -
case reports in dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.338
H-Index - 18
ISSN - 1662-6567
DOI - 10.1159/000522033
Subject(s) - case and review
Association of vulvar Crohn’s disease (CD) with pyoderma gangrenosum (PG) has been described, yet due to its low prevalence, data on therapeutic management of this association are still limited. We here present a 22-year-old woman with severe vulvar and perianal CD with a major inguinal and perineal ulceration. In the hypothesis of an associated PG, oral corticosteroids were prescribed at a dose of 40 mg with limited efficacy for a duration of 3 months. Afterward, a combination treatment of cyclosporine and infliximab followed by negative pressure wound therapy and split-thickness skin graft resulted in complete healing.