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Background:   Stereology is the science of inferring quantitative features of 3-dimensional structures from lower dimensional samples of those structures (probes). It is a statistical discipline and therefore may seem intimidating to many potential users. Without a proper understanding of its principles, though, errors may be made in the quantitative reporting of structural research results.   Summary:   This review article attempts to explain and justify the basic principles of stereology as applied to the glomerulus in a simple and accessible way. A few common errors in application are described. The strengths and weaknesses of “biased” (model-based) stereology are described as well as the basics of design-based (“unbiased”) stereology.   Key Messages:   Stereology is a useful body of theory and practices when quantitation of structural histological features of the glomerulus is desired.

An Introduction to Stereology with Applications to the Glomerulus