Open AccessCarotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period
Author(s) -
Baradaran Hediyeh,
Delic Alen,
McNally J. Scott,
Alexander Matthew,
Majersik Jennifer J.,
Parker Dennis L.,
de Have Adam
Publication year - 2021
Publication title -
dementia and geriatric cognitive disorders extra
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 16
ISSN - 1664-5464
DOI - 10.1159/000518234
Subject(s) - research article
: We evaluated the association between carotid compliance, a measure of arterial stiffness, to parahippocampal volume (PHV) and hippocampal volume (HV) over 20 years later in the Atherosclerosis Risk in the Community study. Methods: We included participants with common carotid compliance measurements at visit 1 (1987–1989) and volumetric brain MRI at visit 5 (2011–2013). The primary outcomes are pooled bilateral PHV and HV. We performed linear regression models adjusting for age, sex, vascular risk factors, and total brain volume. Results: Of the 614 participants, higher compliance was correlated with higher PHV ( R = 0.218[0.144–0.291], p < 0.001) and HV ( R = 0.181 [0.105–0.255, p < 0.001]). The association was linear and significant after adjusting for confounders. At follow-up MRI, 30 patients with dementia had lower PHV and HV than patients without dementia ( p < 0.001 and p < 0.001, respectively). Conclusion: Carotid compliance is associated with higher PHV and HV when measured 20 years later, further supporting the link between arterial stiffness and cognitive decline.