Open AccessRacial-Ethnic Differences in Health-Related Quality of Life among Adults and Children with Glomerular Disease
Author(s) -
Krissberg Jill R.,
Helmuth Margaret E.,
Almaani Salem,
Cai Yi,
Cattran Daniel,
Chatterjee Debanjana,
Gbadegesin Rasheed A.,
Gibson Keisha L.,
Glenn Dorey A.,
Greenbaum Laurence A.,
Iragorri Sandra,
Jain Koyal,
Khalid Myda,
Kidd Jason M.,
Kopp Jeffrey B.,
Lafayette Richard,
Nestor Jordan G.,
Parekh Rulan S.,
Reidy Kimberly J.,
Selewski David T.,
Sperati C. John,
Tuttle Katherine R.,
Twombley Katherine,
Vasylyeva Tetyana L.,
Weaver Donald Jack,
Wenderfer Scott E.,
O’Shaughnessy Michelle M.
Publication year - 2021
Publication title -
glomerular diseases
Language(s) - English
Resource type - Journals
ISSN - 2673-3633
DOI - 10.1159/000516832
Subject(s) - research article
Disparities in health-related quality of life (HRQOL) have been inadequately studied in patients with glomerular disease. The aim of this study was to identify relationships among race/ethnicity, socioeconomic status, disease severity, and HRQOL in an ethnically and racially diverse cohort of patients with glomerular disease. Methods: Cure Glomerulonephropathy (CureGN) is a multinational cohort study of patients with biopsy-proven glomerular disease. Associations between race/ethnicity and HRQOL were determined by the following: (1) missed school or work due to kidney disease and (2) responses to Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires. We adjusted for demographics, socioeconomic status, and disease characteristics using multivariable logistic and linear regression. Results: Black and Hispanic participants had worse socioeconomic status and more severe glomerular disease than white or Asian participants. Black adults missed work or school most frequently due to kidney disease (30 vs. 16–23% in the other 3 groups, p = 0.04), and had the worst self-reported global physical health (median score 44.1 vs. 48.0–48.2, p < 0.001) and fatigue (53.8 vs. 48.5–51.1, p = 0.002), compared to other racial/ethnic groups. However, these findings were not statistically significant with adjustment for socioeconomic status and disease severity, both of which were strongly associated with HRQOL in adults. Among children, disease severity but not race/ethnicity or socioeconomic status was associated with HRQOL. Conclusions: Among patients with glomerular disease enrolled in CureGN, the worse HRQOL reported by black adults was attributable to lower socioeconomic status and more severe glomerular disease. No racial/ethnic differences in HRQOL were observed in children.