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AbstractA proton pump inhibitor (PPI)-associated hyperplastic polyp (HP) in the non- Helicobacter pylori -infected stomach is rare, and its endoscopic features remain poorly described. A 42-year-old man with tarry stool was referred to our hospital for examination and treatment. He had taken PPI for 14 years and was confirmed to be  H. pylori -negative. Transnasal endoscopy revealed bleeding from a 20-mm, reddish pedunculated polyp with a nodular surface, located in the greater curvature of the upper gastric body. Endoscopic mucosal resection was performed, and the lesion was diagnosed as an HP. To our knowledge, this report represents a valuable addition to the HP literature describing a rare case of PPI-associated large HP in the non- H. pylori -infected stomach.

Proton Pump Inhibitor-Associated Large Hyperplastic Polyp in Non- Helicobacter pylori -Infected Stomach