Open AccessLung Adenocarcinoma with Cheek Dysesthesia as an Initial Symptom: A Case Report and Literature Review
Author(s) -
Bandoh Nobuyuki,
Ichikawa Haruyuki,
Asahi Atsuyoshi,
Kono Michihisa,
Harabuchi Shohei,
Sato Ryosuke,
Uemura Akihiro,
Goto Takashi,
Yamaguchi Tomomi,
Kato Yasutaka,
Furukawa Hironori,
Takei Hidehiro,
Harabuchi Yasuaki
Publication year - 2019
Publication title -
case reports in oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 19
ISSN - 1662-6575
DOI - 10.1159/000502053
Subject(s) - case report
Metastasis from lung carcinoma to the sphenoid bone is rare. Patients with symptoms related to sphenoid bone metastasis as the initial presentation of carcinoma are thus also rare. Herein, we report the case of a patient presenting with only cheek dysesthesia as the first sign of lung adenocarcinoma. The 74-year-old woman presented with a 2-month history of left cheek dysesthesia. CT showed a tumor around 2.5 cm in diameter with heterogeneous enhancement of the central focus at the left foramen rotundum in the sphenoid bone. We endoscopically biopsied the tumor through the left sphenoid sinus. Results of histologic examination were consistent with lung adenocarcinoma. FDG-PET/CT analysis demonstrated lung carcinoma that had already metastasized to mediastinal lymph nodes and multiple bones, such as the ribs and lumbar vertebras, in addition to the sphenoid bone. As EGFR gene mutation (p.L858R) was identified, the patient was treated with oral gefinitib. This treatment proved quite effective, and the patient remains alive without tumor growth as of 18 months.