Open AccessTreatment of Head and Neck Cancer with Photodynamic Therapy with Redaporfin: A Clinical Case Report
Author(s) -
Lúcio Lara Santos,
Júlio Oliveira,
Eurico Monteiro,
Juliana Santos,
Cristina Sarmento
Publication year - 2018
Publication title -
case reports in oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.365
H-Index - 19
ISSN - 1662-6575
DOI - 10.1159/000493423
Subject(s) - medicine , photodynamic therapy , head and neck cancer , radiation therapy , oncology , systemic therapy , head and neck squamous cell carcinoma , basal cell , head and neck , combination therapy , cancer , immunotherapy , dermatology , surgery , breast cancer , chemistry , organic chemistry
Advanced head and neck squamous cell carcinoma, after locoregional treatment and multiple lines of systemic therapies, represents a great challenge to overcome acquired resistance. The present clinical case illustrates a successful treatment option and is the first to describe the use of photodynamic therapy (PDT) with Redaporfin, followed by immune checkpoint inhibition with an anti-PD1 antibody. This patient presented an extensive tumor in the mouth pavement progressing after surgery, radiotherapy, and multiple lines of systemic treatment. PDT with Redaporfin achieved the destruction of all visible tumor, and the sequential use of an immune checkpoint inhibitor allowed a sustained complete response. This case is an example of the effect of this therapeutic combination and may provide the basis for a new treatment modality.