Open AccessA Case of Annular Elastolytic Giant Cell Granuloma Associated with Syphilis
Author(s) -
Xiaoping Li,
Wei Zhang,
Yeqiang Liu,
Mingyuan Xu
Publication year - 2018
Publication title -
case reports in dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.338
H-Index - 18
ISSN - 1662-6567
DOI - 10.1159/000489910
Subject(s) - giant cell , medicine , granuloma annulare , granuloma , pathology , hydroxychloroquine , syphilis , pathogenesis , dermatology , histiocyte , granulomatous disease , phagocytosis , disease , immunology , human immunodeficiency virus (hiv) , infectious disease (medical specialty) , covid-19
Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized by annular patches with slightly raised borders, hypopigmented and/or atrophic centers found mainly on sun-exposed skin. Histologically, it is characterized by phagocytosis of elastic fibers by multinucleated giant cells. The pathogenesis of the disease is unclear. We report a case of 55-year-old man with AEGCG in association with syphilis, whose condition improved when hydroxychloroquine sulfate and topical tacrolimus were administered over a 2-month period.