Open AccessChinese Herbal Medicine Alleviates Thyroidectomy-Induced Cardiopulmonary Exercise Dysfunction in Rats
Author(s) -
Tai Yuan Chuang,
ChiaYing Lien,
Chih Hsiang Hsu,
Chen Wen Lu,
Chung Hsin Wu
Publication year - 2020
Publication title -
evidence-based complementary and alternative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.552
H-Index - 90
eISSN - 1741-4288
pISSN - 1741-427X
DOI - 10.1155/2020/9415082
Subject(s) - medicine , cardiac function curve , triiodothyronine , thyroidectomy , endocrinology , respiratory quotient , subcutaneous injection , ejection fraction , respiratory exchange ratio , vo2 max , heart failure , thyroid , heart rate , blood pressure
Hypothyroidism frequently causes cardiopulmonary dysfunction, such as heart failure and respiratory and metabolic deficiencies. This study investigated the effects of Chinese herbal formula B307 on thyroidectomy-induced cardiopulmonary exercise dysfunction in rats. Twenty male rats were equally divided into four groups: negative control with sham treatment, positive control with oral B307 treatment only, thyroidectomy treatment only, and thyroidectomy with B307 posttreatment groups. The feeding dose of B307 was 50 mg/kg per day for 14 days. We examined and then compared the thyroid-stimulating hormone (TSH), free triiodothyronine (T3), free thyroxine (T4), and reactive oxygen species (ROS) from the blood of these four groups. Also, we compared the body weight, neck subcutaneous blood flow, cardiac ejection function, cardiopulmonary exercise function of oxygen consumption (VO 2 ), carbon dioxide production (VCO 2 ), and respiratory quotient (RQ = VCO 2 /VO 2 ) among the four groups. Our results indicated that thyroidectomized rats had significantly decreased body weight, neck subcutaneous blood flow, cardiac ejection function, serum T3 and T4, and VO 2 and VCO 2 , but had significantly increased ROS and TSH levels and RQ values compared with sham rats ( P < 0.01–0.05). In addition, thyroidectomized rats receiving oral B307 treatment had significantly increased body weight, neck subcutaneous blood flow, cardiac ejection function, and VO 2 , but significantly decreased ROS and TSH levels and VCO 2 and RQ values compared with thyroidectomized rats ( P < 0.01–0.05). We suggest that the B307 could be a protective and beneficial alternative treatment for thyroidectomy-induced cardiopulmonary exercise dysfunction.