Open AccessAntiepithelial-Mesenchymal Transition of Herbal Active Substance in Tumor Cells via Different Signaling
Author(s) -
Xiaoji Cui,
Qinlu Lin,
Ping Huang,
Ying Liang
Publication year - 2020
Publication title -
oxidative medicine and cellular longevity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.494
H-Index - 93
eISSN - 1942-0900
pISSN - 1942-0994
DOI - 10.1155/2020/9253745
Subject(s) - epithelial–mesenchymal transition , mesenchymal stem cell , cancer research , metastasis , transcription factor , signal transduction , hypoxia (environmental) , wound healing , biology , transition (genetics) , microbiology and biotechnology , chemistry , gene , cancer , immunology , biochemistry , genetics , organic chemistry , oxygen
Epithelial-mesenchymal transition (EMT) is a biological process through which epithelial cells differentiate into mesenchymal cells. EMT plays an important role in embryonic development and wound healing; however, EMT also contributes to some pathological processes, such as tumor metastasis and fibrosis. EMT mechanisms, including gene mutation and transcription factor regulation, are complicated and not yet well understood. In this review, we introduce some herbal active substances that exert antitumor activity through inhibiting EMT that is induced by hypoxia, high blood glucose level, lipopolysaccharide, or other factors.