Open AccessCombination of Alcohol and EVOH as a New Embolic Agent: Midterm Tissue and Inflammatory Effects in a Swine Model
Author(s) -
Jean-François Hak,
Farouk Tradi,
Mickaël Bobot,
Pauline Brige,
Paul Habert,
Sophie Chopinet,
Aurélie Haffner,
Gilles Soulez,
Benjamin Guillet,
Vincent Vidal
Publication year - 2020
Publication title -
radiology research and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.125
H-Index - 5
eISSN - 2090-1941
pISSN - 2090-195X
DOI - 10.1155/2020/8831060
Subject(s) - medicine , embolization , alcohol , toxicity , kidney , necrosis , surgery , anesthesia , urology , biochemistry , chemistry
Objective To evaluate the vascular occlusion and midterm tissue toxicity properties of a combination of ethylene-vinyl alcohol (EVOH) (Squid 18®) (75%) and alcohol (25%)—Alco-Squid 18—in a swine model.Materials and Methods Alco-Squid 18 (75% Squid 18® mixed with 25% alcohol) (AS18) was compared to embolization with 96% alcohol alone and to embolization with Squid 18® (S18®) alone. An arteriovenous malformation (AVM) model was created in group 1 ( n = 2). Each AVM model was then embolized with AS18 or S18® alone with evaluation of a ratio between the volume of embolic agent divided by the volume of the AVM (evaluated by CT). For group 2 ( n = 5), each agent was tested on three different kidneys (upper pole kidney artery). Pre- and postinterventional CTs, angiographies, blood alcohol content dosages, and histological studies (3 months postintervention) were performed.Results AS18 has better distal distribution than S18® alone, both in the kidneys (mean capsule-S18® distance: 3.9 mm (±0.23) and mean capsule-AS18 distance: 2.3 mm (±0.11) ( p =0.029) and in the AVM model. Histological exploration found a higher rate of tubular necrosis with AS18 compared with S18® alone and alcohol alone (3.78 ± 0.44 compared to 2.33 ± 1.22 ( p = 0.012) and 1.22 ± 0.67 ( p < 0 .0001)). The blood alcohol content was negligible in all cases.Conclusion AS18 can suggest a better distal sclerotic and embolic character as compared with S18® alone without systemic toxicity.