Open AccessConcise Review: The Regulatory Mechanism of Lysine Acetylation in Mesenchymal Stem Cell Differentiation
Author(s) -
Hong Yang,
Yuexia Liu,
Xuanchen Liu,
Huihui Gu,
Jing Zhang,
Chao Sun
Publication year - 2020
Publication title -
stem cells international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.205
H-Index - 64
eISSN - 1687-9678
pISSN - 1687-966X
DOI - 10.1155/2020/7618506
Subject(s) - mesenchymal stem cell , lysine , epigenetics , acetylation , nerve repair , cellular differentiation , microbiology and biotechnology , stem cell , biology , bioinformatics , gene , genetics , regeneration (biology) , amino acid
Nowadays, the use of MSCs has attracted considerable attention in the global science and technology field, with the self-renewal and multidirectional differentiation potential for diabetes, obesity treatment, bone repair, nerve repair, myocardial repair, and so on. Epigenetics plays an important role in the regulation of mesenchymal stem cell differentiation, which has become a research hotspot in the medical field. This review focuses on the role of lysine acetylation modification on the determination of MSC differentiation direction. During this progress, the recruitment of lysine acetyltransferases (KATs) and lysine deacetylases (KDACs) is the crux of transcriptional mechanisms in the dynamic regulation of key genes controlling MSC multidirectional differentiation.