Open Accessp53: A Key Protein That Regulates Pulmonary Fibrosis
Author(s) -
Qi Wu,
Kejia Zhang,
Shuting Jiang,
Lu Fu,
Yue Shi,
Rubin Tan,
Jie Cui,
Yao Zhou
Publication year - 2020
Publication title -
oxidative medicine and cellular longevity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.494
H-Index - 93
eISSN - 1942-0900
pISSN - 1942-0994
DOI - 10.1155/2020/6635794
Subject(s) - pulmonary fibrosis , pathogenesis , carcinogenesis , disease , medicine , fibrosis , cancer research , idiopathic pulmonary fibrosis , apoptosis , bioinformatics , lung , pathology , cancer , biology , genetics
Pulmonary fibrosis is a progressively aggravating lethal disease that is a serious public health concern. Although the incidence of this disease is increasing, there is a lack of effective therapies. In recent years, the pathogenesis of pulmonary fibrosis has become a research hotspot. p53 is a tumor suppressor gene with crucial roles in cell cycle, apoptosis, tumorigenesis, and malignant transformation. Previous studies on p53 have predominantly focused on its role in neoplastic disease. Following in-depth investigation, several studies have linked it to pulmonary fibrosis. This review covers the association between p53 and pulmonary fibrosis, with the aim of providing novel ideas to improve the clinical diagnosis, treatment, and prognosis of pulmonary fibrosis.