Open AccessAn Overview of Lipid Metabolism and Nonalcoholic Fatty Liver Disease
Author(s) -
Ke Pei,
Ting Gui,
Dongfang Kan,
Huichao Feng,
Yang Jin,
Ying Yang,
Qian Zhang,
Ziwei Du,
Zhibo Gai,
Jibiao Wu,
Yunlun Li
Publication year - 2020
Publication title -
biomed research international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 126
eISSN - 2314-6141
pISSN - 2314-6133
DOI - 10.1155/2020/4020249
Subject(s) - nonalcoholic fatty liver disease , lipid metabolism , fatty liver , ceramide , medicine , arachidonic acid , disease , metabolism , fatty acid , endocrinology , biology , biochemistry , enzyme , apoptosis
The occurrence of nonalcoholic fatty liver disease (NAFLD) is associated with major abnormalities of hepatic lipid metabolism. We propose that lipid abnormalities directly or indirectly contribute to NAFLD, especially fatty acid accumulation, arachidonic acid metabolic disturbance, and ceramide overload. The effects of lipid intake and accumulation on NAFLD and NAFLD treatment are explained with theoretical and experimental details. Overall, these findings provide further understanding of lipid metabolism in NAFLD and may lead to novel therapies.