Open AccessHydroethanolic Extract from Bridelia atroviridis Müll. Arg. Bark Improves Haematological and Biochemical Parameters in Nicotinamide-/Streptozotocin-Induced Diabetic Rats
Author(s) -
Clarice Noussi Djouwoug,
Florence Tsofack Ngueguim,
Racéline Kamkumo Gounoue,
Clémence Donfack Gouni,
Antoine Kavaye Kandeda,
Jean Philippe Djientcheu,
Rodrigue Fifen,
Désiré Paul Djomeni Dzeufiet,
Silvère Ngouela,
Norbert Sewald,
Bruno Ndjakou Lenta,
Théophile Dimo
Publication year - 2020
Publication title -
evidence-based complementary and alternative medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.552
H-Index - 90
eISSN - 1741-4288
pISSN - 1741-427X
DOI - 10.1155/2020/3160834
Subject(s) - streptozotocin , oxidative stress , proinflammatory cytokine , medicine , diabetes mellitus , antioxidant , insulin resistance , leukocytopenia , traditional medicine , glutathione , pharmacology , endocrinology , chemistry , inflammation , biochemistry , toxicity , enzyme
Bridelia atroviridis Müll. Arg. (B. atroviridis ) is a plant used in Cameroonian traditional medicine to manage diabetes. The effects of hydroethanolic barks extract from B. atroviridis were evaluated on diabetes disorders including hematology, inflammatory, and oxidative stress parameters. The in vitro antioxidant capacity of the hydroethanolic bark extract (70 : 30) was evaluated. Nicotinamide-/streptozotocin-induced diabetic rats were daily treated with the B. atroviridis extract for fifteen days. Glycemia were evaluated every 5 days, insulin sensibility test was performed, and haematological, inflammatory, and oxidative stress parameters were analysed. Histomorphometry of the pancreas was realized. The extract was able to scavenge free radicals in vitro and decrease significantly the blood glucose levels. The treatment resulted in a significant alleviation of insulin resistance, anemia, leukocytopenia, and thrombocytopenia observed in untreated diabetic rats. The extract significantly decreased proinflammatory cytokines TNF- α , IL-1 β , and IL-10. The rate of reduced glutathione was increased in the pancreas, whereas the catalase activity and nitrite concentration were decreased. Diabetic control showed a reduced size of Langerhans islet, whereas the size of islets was large in treated groups. The hydroethanolic extract of B. atroviridis was able to improve glycemia and alleviate haematological and inflammatory parameters disorders observed in diabetic conditions, probably due to its antidiabetic, anti-inflammatory, and antioxidant capacities.