Open AccessRoles of Reactive Oxygen Species in Biological Behaviors of Prostate Cancer
Author(s) -
Chenglin Han,
Zilong Wang,
Yingkun Xu,
Shuxiao Chen,
Yaling Han,
Lin Li,
Muwen Wang,
Xunbo Jin
Publication year - 2020
Publication title -
biomed research international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 126
eISSN - 2314-6141
pISSN - 2314-6133
DOI - 10.1155/2020/1269624
Subject(s) - reactive oxygen species , prostate cancer , biology , microbiology and biotechnology , signal transduction , cancer , intracellular , antioxidant , cancer research , homeostasis , programmed cell death , bioinformatics , apoptosis , biochemistry , genetics
Prostate cancer (PCa), known as a heterogenous disease, has a high incidence and mortality rate around the world and seriously threatens public health. As an inevitable by-product of cellular metabolism, reactive oxygen species (ROS) exhibit beneficial effects by regulating signaling cascades and homeostasis. More and more evidence highlights that PCa is closely associated with age, and high levels of ROS are driven through activation of several signaling pathways with age, which facilitate the initiation, development, and progression of PCa. Nevertheless, excessive amounts of ROS result in harmful effects, such as genotoxicity and cell death. On the other hand, PCa cells adaptively upregulate antioxidant genes to detoxify from ROS, suggesting that a subtle balance of intracellular ROS levels is required for cancer cell functions. The current review discusses the generation and biological roles of ROS in PCa and provides new strategies based on the regulation of ROS for the treatment of PCa.