Open AccessMouse IgG2a Antibodies Specific for the CommensalStreptococcus mitisShow Stronger Cross-Reactivity withStreptococcus pneumoniaethan IgG1 Antibodies
Author(s) -
Sudhanshu Shekhar,
Rabia Khan,
Ata Ul Razzaq Khan,
Fernanda Cristina Petersen
Publication year - 2019
Publication title -
journal of immunology research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.315
H-Index - 83
eISSN - 2314-8861
pISSN - 2314-7156
DOI - 10.1155/2019/7906724
Subject(s) - streptococcus pneumoniae , streptococcus mitis , antibody , microbiology and biotechnology , serotype , isotype , cross reactivity , biology , pneumococcal infections , streptococcus , immunology , virology , bacteria , cross reactions , monoclonal antibody , antibiotics , genetics
Here we show that mouse IgG2a and IgG1 antibodies specific for the commensal Streptococcus mitis cross-react with pathogen Streptococcus pneumoniae serotypes 2 and 4, although the cross-reactivity conferred by IgG2a is stronger than that by IgG1 antibodies. These findings may be important for understanding the S. mitis -induced IgG isotype responses and have consequences for the development of an effective pneumococcal vaccine.