Open AccessInterleukin-1 Beta Gene Polymorphism rs16944 May Associate with Increased Susceptibility to Extremity Chronic Osteomyelitis in Chinese Han Population
Author(s) -
Zilong Yao,
Qing Lin,
Yanjun Hu,
Yilong Hou,
Yunfei Ma,
Bin Yu,
Nan Jiang
Publication year - 2019
Publication title -
biomed research international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 126
eISSN - 2314-6141
pISSN - 2314-6133
DOI - 10.1155/2019/7483537
Subject(s) - single nucleotide polymorphism , genotype , genotyping , genetics , biology , allele , allele frequency , polymorphism (computer science) , gene polymorphism , population , genetic model , gene , medicine , environmental health
Background Previous studies had indicated that interleukin-1 beta (IL-1 β ) gene single nucleotide polymorphisms (SNPs) associate with different inflammatory diseases. However, potential links between these polymorphisms and susceptibility to extremity chronic osteomyelitis (COM) remain unclear. This study aimed to investigate relationships between IL-1 β gene polymorphisms (rs16944, rs1143627, rs1143634, and rs2853550) and risks of developing extremity COM in Chinese Han population.Methods Altogether 233 extremity COM patients and 200 healthy controls were genotyped for the four tag SNPs of the IL-1 β gene using the SNapShot genotyping method. Comparisons were performed regarding genotype distribution, mutant allele frequency, and four genetic models (dominant, recessive, homozygous, and heterozygous models) of the four SNPs between the two groups.Results Significant associations were identified between rs16944 polymorphism and the risk of developing COM by dominant model ( P = 0.026, OR = 1.698, 95% CI 1.065-2.707) and heterozygous model ( P = 0.030, OR = 1.733, 95% CI 1.055-2.847). Although no statistical differences were found of rs1143627 polymorphism between the two groups, there existed a trend that rs1143627 may be linked to an elevated risk of developing COM by outcomes of dominant ( P = 0.061), homozygous ( P = 0.080) and heterozygous ( P = 0.095) models. However, no statistical correlations were found between rs1143634 and rs2853550 polymorphisms and susceptibility to COM in Chinese Han population.Conclusions To our knowledge, we reported for the first time that IL-1 β gene rs16944 polymorphism may contribute to the increased susceptibility to extremity COM in Chinese Han population, with genotype of AG as a risk factor.