Open AccessAcute Myeloid Leukemia with Concomitant BCR-ABL and NPM1 Mutations
Author(s) -
Benedetta Mariotti,
Federico Meconi,
Raffaele Palmieri,
Eleonora De Bellis,
Serena Lavorgna,
Tiziana Ottone,
Vincenza Martini,
Francesco LoCoco,
Laura Cicconi
Publication year - 2019
Publication title -
case reports in hematology
Language(s) - English
Resource type - Journals
eISSN - 2090-6560
pISSN - 2090-6579
DOI - 10.1155/2019/6707506
Subject(s) - npm1 , medicine , myeloid leukemia , nucleophosmin , breakpoint cluster region , concomitant , cancer research , mutation , abl , leukemia , immunology , genetics , karyotype , gene , biology , tyrosine kinase , receptor , chromosome
We present a case report of a patient with acute myeloid leukemia (AML) characterized by the simultaneous presence of nucleophosmin 1 (NPM1) mutation and the breakpoint cluster region-Abelson (BCR-ABL) fusion oncogene. Our findings emphasize the importance of routinely including BCR-ABL in the diagnostic workup of AML in order to offer to the patients the most appropriate risk category and treatment options.