Open AccessSynthesis of Ag@Fe3O4 Nanoparticles for Photothermal Treatment of Ovarian Cancer
Author(s) -
Bing Liu,
Jian Zhou,
Bin Zhang,
Jing Qu
Publication year - 2019
Publication title -
journal of nanomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.463
H-Index - 66
eISSN - 1687-4129
pISSN - 1687-4110
DOI - 10.1155/2019/6457968
Subject(s) - photothermal therapy , materials science , nanoparticle , irradiation , photothermal effect , cancer cell , cell growth , ovarian cancer , cancer , apoptosis , nanotechnology , biophysics , chemistry , medicine , biochemistry , biology , physics , nuclear physics
Photothermal therapy is a promising approach for cancer treatment. In our study, we investigate the photothermal effect of different concentrations of the Ag@Fe 3 O 4 nanoparticles on apoptosis and proliferation in the human epithelial ovarian cancer cells SKOV3. Ovarian cancer cells SKOV3 were treated with the Ag@Fe 3 O 4 nanoparticles under an 808 nm near-infrared (NIR) laser irradiation at different concentrations. The cell proliferation was measured by the cell counting kit-8 (CCK-8) assay. The results show that the Ag@Fe 3 O 4 nanoparticles with NIR laser irradiation could markedly inhibit the proliferation of the ovarian cancer cells SKOV3 independent of a concentration-time manner. Meanwhile, the cell morphology was also seriously damaged under the treatment of high-concentration nanoparticles. However, Ag@Fe 3 O 4 nanoparticles have almost no obvious effect on the growth of SKOV3 cells without NIR laser illumination treatment. Therefore, it is reasonable to believe that the Ag@Fe 3 O 4 nanoparticles have promising applications in photothermal treatment of cancer cells.