Open AccessReactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis
Author(s) -
Shashank Shrishrimal,
Elizabeth A. Kosmacek,
Rebecca E. OberleyDeegan
Publication year - 2019
Publication title -
oxidative medicine and cellular longevity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.494
H-Index - 93
eISSN - 1942-0900
pISSN - 1942-0994
DOI - 10.1155/2019/4278658
Subject(s) - reactive oxygen species , epigenetics , myofibroblast , extracellular matrix , fibroblast , fibrosis , microbiology and biotechnology , antioxidant , biology , chemistry , cancer research , genetics , medicine , biochemistry , pathology , in vitro , gene
Radiation-induced fibrosis (RIF) develops months to years after initial radiation exposure. RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant amounts of extracellular matrix proteins. One of the main drivers for developing RIF is reactive oxygen species (ROS) generated immediately after radiation exposure. Generation of ROS is known to induce epigenetic changes and cause differentiation of fibroblasts to myofibroblasts. Several antioxidant compounds have been shown to prevent radiation-induced epigenetic changes and the development of RIF. Therefore, reviewing the ROS-linked epigenetic changes in irradiated fibroblast cells is essential to understand the development and prevention of RIF.