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A novel Mn 2+ -doped hollow Mn-HMAS aluminosilica (Mn-HMAS) nanoparticle for simultaneousT    1    -weighted magnetic resonance imaging and drug delivery was reported. The magnetic resonance tests showed that the Mn-HMAS nanoparticles display an excellentT    1    -weighted magnetic resonance imaging effect with a highT    1relaxivity (r1) of 8.8 mM -1 S -1 . The MTT assays showed that the Mn-HMAS-DOX nanoparticles possess a better tumour cell inhibition effect than DOX. In addition, the Mn-HMAS nanoparticles also exhibit good stability and noncytotoxicity. These results demonstrated that the Mn-HMAS nanoparticles can be applied for the loading and delivery of various drugs in medicine.

journal of nanomaterials

Fabrication of Mn<sup>2+</sup>-Doped Hollow Mesoporous Aluminosilica Nanoparticles for Magnetic Resonance Imaging and Drug Delivery for Therapy of Colorectal Cancer

Fabrication of Mn2+-Doped Hollow Mesoporous Aluminosilica Nanoparticles for Magnetic Resonance Imaging and Drug Delivery for Therapy of Colorectal Cancer

Fabrication of Mn²⁺-Doped Hollow Mesoporous Aluminosilica Nanoparticles for Magnetic Resonance Imaging and Drug Delivery for Therapy of Colorectal Cancer