Open AccessComparative Evaluation of 68Ga-Citrate PET/CT and 18F-FDG PET/CT in the Diagnosis of Type II Collagen-Induced Arthritis in Rats
Author(s) -
Zi Wang,
Liang Cai,
Tingting Xu,
Dan Tang,
Lin Liu,
Yue Chen
Publication year - 2019
Publication title -
contrast media and molecular imaging/contrast media and molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.714
H-Index - 50
eISSN - 1555-4317
pISSN - 1555-4309
DOI - 10.1155/2019/2353658
Subject(s) - medicine , rheumatoid arthritis , nuclear medicine , arthritis , ankle , standardized uptake value , h&e stain , synovitis , positron emission tomography , staining , pathology
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic, symmetrical, and erosive synovitis. RA is one of the most common disabling diseases in the clinic. The main clinical intervention strategies are early diagnosis and early treatment. This study aims to predict the diagnostic value of 68 Ga-citrate and 18 F-FDG PET/CT in RA by comparing and analyzing the value of 68 Ga-citrate and 18 F-FDG PET/CT for diagnosing type II collagen-induced arthritis (CIA) in rats. Some CIA models were established. Normal rats were selected as the control group, and 23 days and 40 days were selected as the early and late time points of arthritis, respectively. The semiquantitative analysis of CIA rats was carried out with 68 Ga-citrate PET/CT and 18 F-FDG PET/CT, and the ratio of the maximum standardized uptake (SUV max ) values in the regions of interest (ROIs) of the hind foot ankle joint and thigh muscle was calculated and statistically analyzed. The distribution of CIA rats in vivo at the 68 Ga-citrate 90 min time point was studied, and the ankle tissues were evaluated with hematoxylin and eosin (HE) staining. 68 Ga-citrate PET/CT is obviously superior to 18 F-FDG PET/CT for CIA imaging, and the statistical results show that the difference between the two examination methods is statistically significant ( P < 0.001). The uptake of these two radiopharmaceuticals showed the same trend in arthritis rats with different scores. The distribution of 68 Ga-citrate at 90 min is consistent with the trend shown by 68 Ga-citrate PET/CT. 68 Ga-citrate PET/CT can reflect the inflammatory activity of affected joints in CIA rats earlier and more sensitively than 18 F-FDG PET/CT, and this imaging advantage continues until the later stage of inflammation. Therefore, 68 Ga-citrate PET/CT is worthy of further promotion and application in the clinical diagnosis of RA.