Open AccessFabrication and Characterization of Scaffolds of Poly(ε-caprolactone)/Biosilicate® Biocomposites Prepared by Generative Manufacturing Process
Author(s) -
Daniel Aparecido Lopes Vieira da Cunha,
Paulo Inforçatti Neto,
Kelli Cristina Micocci,
Caroline Faria Bellani,
Heloísa Sobreiro Selistre-de-Araújo,
Zilda de Castro Silveira,
Márcia Cristina Branciforti
Publication year - 2019
Publication title -
international journal of biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.576
H-Index - 28
eISSN - 1687-8795
pISSN - 1687-8787
DOI - 10.1155/2019/2131467
Subject(s) - caprolactone , extrusion , scaffold , interconnectivity , materials science , tissue engineering , biocomposite , biomedical engineering , chemistry , composite material , copolymer , polymer , composite number , medicine , artificial intelligence , computer science
Scaffolds of poly( ε -caprolactone) (PCL) and their biocomposites with 0, 1, 3, and 5 wt.% Biosilicate® were fabricated by the generative manufacturing process coupled with a vertical miniscrew extrusion head to application for restoration of bone tissue. Their morphological characterization indicated the designed 0°/90° architecture range of pore sizes and their interconnectivity is feasible for tissue engineering applications. Mechanical compression tests revealed an up to 57% increase in the stiffness of the scaffold structures with the addition of 1 to 5 wt.% Biosilicate® to the biocomposite. No toxicity was detected in the scaffolds tested by in vitro cell viability with MC3T3-E1 preosteoblast cell line. The results highlighted the potential application of scaffolds fabricated with poly( ε -caprolactone)/Biosilicate® to tissue engineering.