Open AccessNeuropeptide B and Vaspin as New Biomarkers in Anorexia Nervosa
Author(s) -
Teresa Grzelak,
Marta TyszkiewiczNwafor,
Agata Dutkiewicz,
Aniceta Ada Mikulska,
Monika DmitrzakWęglarz,
Agnieszka Słopień,
Krystyna Czyżewska,
Elżbieta Paszyńska
Publication year - 2018
Publication title -
biomed research international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 126
eISSN - 2314-6141
pISSN - 2314-6133
DOI - 10.1155/2018/9727509
Subject(s) - anorexia nervosa , anthropometry , medicine , cohort , endocrinology , population , neuropeptide y receptor , neuropeptide , gastroenterology , eating disorders , psychiatry , receptor , environmental health
The aim of the study was to assess the correlation between the levels of neuropeptide B (NPB), neuropeptide W (NPW), vaspin (VAS), and the total antioxidant status (TAS) in the blood, as well as nutritional status of patients with anorexia nervosa (AN).Materials and Methods The study covered a cohort of 76 female teenagers, including 46 females with extreme AN and 30 healthy peers (CONTR) aged 12-17.Results AN persons were characterized by higher (in comparison to CONTR) NPB and VAS concentrations and lower values of TAS levels, body weight, and anthropometric values. Positive correlations between NPB and VAS levels were noted in the AN group (R=0.33; p<0.001) as well as between concentrations of NPW and VAS in the same group (R=0.49; p<0.001). Furthermore, positive correlations existed between NPB and NPW concentrations across the whole studied population (AN+CONTR; R=0.75; p<0.1), AN (R=0.73; p<0.1) and CONTR (R=0.90; p<0.0005).Conclusions In detailed diagnostics of AN it is worth considering testing NPB and VAS levels.