Open AccessFolate-Functionalized Mesoporous Hollow SnO2 Nanofibers as a Targeting Drug Carrier to Improve the Antitumor Effect of Paclitaxel for Liver Cancer Therapy
Author(s) -
Huiling Lv,
Chao Wu,
Xuan Li,
Andi Bai,
Yue Cao,
Wenjing Shang,
Lili Hu,
Ying Liu
Publication year - 2018
Publication title -
biomed research international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 126
eISSN - 2314-6141
pISSN - 2314-6133
DOI - 10.1155/2018/8526190
Subject(s) - paclitaxel , drug , mesoporous material , pharmacology , nanofiber , chemistry , liver cancer , drug carrier , cancer research , cancer , nanotechnology , materials science , medicine , biochemistry , catalysis
In this study, we prepared PTX-loaded mesoporous hollow SnO 2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state. The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX. Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells. Therefore, SFNF is a promising targeting antitumor drug delivery carrier.