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Background . Parkinson's disease (PD) is an age-related neurodegenerative disease affected by multiple genetic and environmental factors. We performed a case-control study on candidate gene to scrutinize whether genetic variants in  LRRK2 ,  SNCA , and  ITGA8  genes could be associated with sporadic PD in Chinese Han population.  Methods . Five single-nucleotide polymorphisms (SNPs) of  LRRK2  (rs1491942),  SNCA  (rs2301134, rs2301135, and rs356221), and  ITGA8  (rs7077361) were selected and genotyped among 583 unrelated PD patients and 558 healthy controls.  Results . Rs1491942 of  LRRK2  gene had a significantly higher genotype frequency ( P  = 3.543E − 09) and allelic G/C frequencies ( P  = 2.601E − 10) in PD patients than controls. Rs2301135 of  SNCA  gene also showed an obvious difference in genotype frequency ( P  = 4.394E − 07) and allelic G/C frequencies ( P  = 9.116E − 13) between PD patients and controls. SNPs rs2301134 and rs356221 of  SNCA  gene and rs7077361 of  ITGA8  gene lacked the significant association with the susceptibility of PD in Chinese Han population.  Conclusions . Our study firstly expresses that rs1491942 of  LRRK2  and rs2301135 of  SNCA  gene are substantially associated with sporadic Parkinson's disease in Chinese Han population.

Analysis ofLRRK2,SNCA,andITGA8Gene Variants with Sporadic Parkinson’s Disease Susceptibility in Chinese Han Population