Open AccessDeficiency of bone morphogenetic protein-3b induces metabolic syndrome and increases adipogenesis
Author(s) -
Íngrid Martí-Pàmies,
Robrecht Thoonen,
Patrick Seale,
Alexia Vite,
Alex Caplan,
Jesus Tamez,
Lauren Graves,
Wei Han,
Emmanuel Buys,
Donald B. Bloch,
Marielle ScherrerCrosbie
Publication year - 2020
Publication title -
endocrinology and metabolism/american journal of physiology: endocrinology and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.507
H-Index - 201
eISSN - 1522-1555
pISSN - 0193-1849
DOI - 10.1152/ajpendo.00362.2019
Subject(s) - adipogenesis , endocrinology , medicine , adipose tissue , bone remodeling , insulin resistance , white adipose tissue , biology , glucose homeostasis , carbohydrate metabolism , metabolic syndrome , insulin , diabetes mellitus
Bone morphogenetic protein (BMP) receptor signaling is critical for the regulation of the endocrine system and cardiovascular structure and function. The objective of this study was to investigate whether Bmp3b, a glycoprotein synthetized and secreted by adipose tissue, is necessary to regulate glucose and lipid metabolism, adipogenesis, and cardiovascular remodeling. Over the course of 4 mo, Bmp3b -knockout ( Bmp3b -/- ) mice gained more weight than wild-type (WT) mice. The plasma levels of cholesterol and triglycerides were higher in Bmp3b -/- mice than in WT mice. Bmp3b -/- mice developed insulin resistance and glucose intolerance. The basal heart rate was higher in Bmp3b -/- mice than in WT mice, and echocardiography revealed eccentric remodeling in Bmp3b -/- mice. The expression of adipogenesis-related genes in white adipose tissue was higher in Bmp3b -/- mice than in WT control mice. In vitro studies showed that Bmp3b modulates the activity of the C/ebpα promoter, an effect mediated by Smad2/3. The results of this study suggest that Bmp3b is necessary for the maintenance of homeostasis in terms of age-related weight gain, glucose metabolism, and left ventricular (LV) remodeling and function. Interventions that increase the level or function of BMP3b may decrease cardiovascular risk and pathological cardiac remodeling.