Open AccessRecent advancement of chemical imaging in pharmaceutical quality control: From final product testing to industrial utilization
Author(s) -
Luming Liu,
Haibin Qu
Publication year - 2019
Publication title -
journal of innovative optical health sciences/journal of innovation in optical health science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 24
eISSN - 1793-5458
pISSN - 1793-7205
DOI - 10.1142/s1793545819300143
Subject(s) - scope (computer science) , quality (philosophy) , computer science , pharmaceutical industry , manufacturing engineering , product (mathematics) , process engineering , pharmaceutical manufacturing , control (management) , dimension (graph theory) , process (computing) , process control , chemical imaging , quality by design , industrial engineering , sample (material) , biochemical engineering , systems engineering , new product development , engineering , artificial intelligence , mathematics , microbiology and biotechnology , business , chemistry , medicine , marketing , philosophy , biology , operating system , geometry , epistemology , chromatography , pharmacology , programming language , pure mathematics , hyperspectral imaging
Chemical imaging (CI) possesses a strong ability of pharmaceutical analysis. Its great strength relies on the integration of traditional spectroscopy (one dimension) and imaging technique (two dimensions) to generate three-dimensional data hypercubes. Data pre-processing or processing methods are proposed to analyze vast data matrixes and thereby realizing different research objectives. In this review paper, various pharmaceutical applications of quality control over the past few years are summed up in two groups of final product test and industrial utilization. The scope of “quality control” here includes traditional analytical use, process understanding and manufactural control. Finally, two major challenges about undesirable sample geometry and lengthy acquisition time are discussed for prospective commercial or industrial application.