Open AccessInfliximab in acute severe colitis: getting the right dose
Author(s) -
Janice Fiske,
Thomas Conley,
Shaji Sebastian,
Sreedhar Subramanian
Publication year - 2020
Publication title -
frontline gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.919
H-Index - 13
eISSN - 2041-4145
pISSN - 2041-4137
DOI - 10.1136/flgastro-2020-101407
Subject(s) - infliximab , medicine , dosing , colitis , intensive care medicine , rescue therapy , tumor necrosis factor alpha
Acute severe colitis is a medical emergency and requires prompt treatment with intravenous steroids. Infliximab is typically used as rescue therapy in those who fail to respond to corticosteroids. This article outlines the altered pharmacokinetics of infliximab in acute severe UC and summarised the latest published data surrounding accelerated infliximab dosing.