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We report the draft genome sequence of the multidrug-resistant Escherichia coli strain PTA A1517-5, isolated from a wastewater treatment plant in Costa Rica. The genome consists of 4,927,375 bp with a GC content of 50.57% and a total of 4,853 genes. This strain harbors bla  CTX-M-115 , bla  CMY-2 , aminoglycoside, tetracycline, and sulfonamide resistance genes.

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Draft Genome Sequence of an Escherichia coli Strain Harboring bla CTX-M-115 , bla CMY-2 , Aminoglycoside, Tetracycline, and Sulfonamide Resistance Genes, Isolated from a Costa Rican Wastewater Treatment Plant