Open AccessComparative Analysis of Colon Cancer-Derived Fusobacterium nucleatum Subspecies: Inflammation and Colon Tumorigenesis in Murine Models
Author(s) -
Jessica Queen,
Jada C. Domingue,
James R. White,
Courtney Stevens,
Barath Udayasuryan,
Tam T.D. Nguyen,
Shaoguang Wu,
Hua Ding,
Hongni Fan,
Madison McMann,
Alina Corona,
Tatianna Larman,
Scott S. Verbridge,
Franck Housseau,
Daniel J. Slade,
Julia L. Drewes,
Cynthia L. Sears
Publication year - 2022
Publication title -
mbio
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.562
H-Index - 121
eISSN - 2161-2129
pISSN - 2150-7511
DOI - 10.1128/mbio.02991-21
Subject(s) - fusobacterium nucleatum , carcinogenesis , biology , microbiology and biotechnology , subspecies , virulence , colorectal cancer , fusobacteria , cancer research , gene , genetics , cancer , bacteria , paleontology , bacteroidetes , 16s ribosomal rna , porphyromonas gingivalis
Colon cancer is a leading cause of cancer morbidity and mortality, and it is hypothesized that dysbiosis in the gut microbiota contributes to colon tumorigenesis.Fusobacterium nucleatum , a member of the oropharyngeal microbiome, is enriched in a subset of human colon tumors. However, it is unclear whether this genetically varied species directly promotes tumor formation, modulates mucosal immune responses, or merely colonizes the tumor microenvironment.