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The mouse genome contains two related interferon-regulated genes,Mx1 andMx2 . WhereasMx1 codes for the nuclear 72-kDa protein that interferes with influenza virus replication after interferon treatment, theMx2 gene is nonfunctional in all laboratory mouse strains examined, since its open reading frame (ORF) is interrupted by an insertional mutation and a subsequent frameshift mutation. In the present study, we demonstrate thatMx2 mRNA of cells from feral mouse strains NJL (Mus musculus musculus ) and SPR (Mus spretus ) differs from that of the laboratory mouse strains tested. TheMx2 mRNA of the feral strains contains a single long ORF consisting of 656 amino acids. We further show that Mx2 protein in the feral strains is expressed upon interferon treatment and localizes to the cytoplasm much like the rat Mx2 protein, which inhibits vesicular stomatitis virus replication. Furthermore, transfected 3T3 cell lines of laboratory mouse origin expressingMx2 from feral strains acquire slight resistance to vesicular stomatitis virus.

journal of virology

Identification of the Murine <i>Mx2</i> Gene: Interferon-Induced Expression of the Mx2 Protein from the Feral Mouse Gene Confers Resistance to Vesicular Stomatitis Virus

Identification of the Murine Mx2 Gene: Interferon-Induced Expression of the Mx2 Protein from the Feral Mouse Gene Confers Resistance to Vesicular Stomatitis Virus