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Studies on the development and function of CD4+ TH 1 and TH 2 cells during the progression to AIDS may increase the understanding of AIDS pathogenesis. The preferential replication of human immunodeficiency virus (HIV) in either TH 1 or TH 2 cells could alter the delicate balance of the immune response. TH 1 (gamma interferon [IFN-γ] positive, interleukin-4 [IL-4] and IL-5 negative) and TH 2 (IFN-γ negative, IL-4 and IL-5 positive) clones, developed from several healthy donors, pedigreed by reverse transcriptase PCR (RT-PCR) and enzyme linked immunosorbent assay have similar levels of cell surface expression of CD4 and several chemokine receptor cofactors necessary for viral entry. After activation by specific antigens and infection with T-cell-tropic strains of HIV type 1 (HIV-1), TH 1 and TH 2 clones showed similar levels of viral entry and reverse transcription. At days 3 through 14 postinfection, HIV replicated to similar levels in several TH 1 and TH 2 clones as measured by release of HIV p24 and total number of copies ofgag RNA/total cell RNA as measured by RT-PCR. When values were normalized for viable cell number in three clones of each type, there was up to twofold more HIV RNA in TH 1 than TH 2 cells. In addition, several primary monocytotropic HIV-1 strains were able to replicate to similar levels in TH 1 and TH 2 cells. These studies suggest that the importance of TH 1 and TH 2 subsets in AIDS pathogenesis transcends clonal differences in their ability to support HIV replication.

Similar Levels of Human Immunodeficiency Virus Type 1 Replication in Human TH1 and TH2 Clones

Similar Levels of Human Immunodeficiency Virus Type 1 Replication in Human T_H1 and T_H2 Clones