Genomic arrangement of an adenovirus-simian virus 40 hybrid virus, Ad2+ND4del | Zendy

H Westphal | Zendy

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Genomic arrangement of an adenovirus-simian virus 40 hybrid virus, Ad2+ND4del

Author(s) -

H Westphal

Publication year - 1981

Publication title -

journal of virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.617

H-Index - 292

eISSN - 1070-6321

pISSN - 0022-538X

DOI - 10.1128/jvi.40.2.526-532.1981

Subject(s) - biology , virus , simian , virology , dna virus , dna , gene , viral transformation , bk virus , adenoviridae , microbiology and biotechnology , genetics , genome , genetic enhancement , kidney , kidney transplantation

Ad2+ND4del is an adenovirus type 2-simian virus 40 hybrid virus nondefective for growth in human cells. The virus was first observed when stocks of Ad2+ND4, a hybrid isolated from primary monkey kidney cells, were propagated in human cells. This paper describes the DNA sequence at two sites of DNA recombination, the site of the left adenovirus type 2-simian virus 40 junction and the site of a deletion of internal simian virus 40 sequences. Since the deletion was observed when the virus was switched from monkey to human cells, an analysis of gene expression in the region of DNA rearrangement may prove useful for the elucidation of molecular events that accompany virus growth in different hosts.

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