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The results of PCR-based molecular typing ofHelicobacter pylori strains by restriction fragment length polymorphism analysis of a 1,161-bp nucleotide sequence of the midregion of thevacA gene are reported. A total of 48H. pylori strains isolated from gastric biopsy specimens obtained from 18 patients with peptic ulcer dyspepsia, 15 patients with nonulcer dyspepsia, and 15 asymptomaticH. pylori -infected subjects were studied. Highly heterogeneous restriction patterns were obtained by digestion of PCR products withSau II,Bgl II, andHha I, whereasHae III digestion resulted in a strictly homogeneous profile forH. pylori strains isolated from 14 of 18 (77.7%) patients with peptic ulcer dyspepsia, but a strictly homogeneous profile was found for strains from only 8 of 15 (53.3%) patients with nonulcer dyspepsia (P = 0.163) and 5 of 15 (33.3%) asymptomaticH. pylori -infected subjects (P = 0.014). A potentially important aspect of the results obtained is the clinical relevance, since a single restriction pattern seems to be able to identify the majority ofH. pylori strains associated with peptic ulcer disease.

journal of clinical microbiology

PCR-Based Restriction Pattern Typing of the <i>vacA</i> Gene Provides Evidence for a Homogeneous Group among <i>Helicobacter pylori</i> Strains Associated with Peptic Ulcer Disease

PCR-Based Restriction Pattern Typing of the vacA Gene Provides Evidence for a Homogeneous Group among Helicobacter pylori Strains Associated with Peptic Ulcer Disease