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Two commercially available, nonsensitized control erythrocytes for use in rubella antibody passive hemagglutination assays detected nonspecific reactions in 10 of 600 (1.7%) and 9 of 500 (1.8%) sera tested. Reactive sera were positive with one or the other cell type, but not both. The probability of obtaining a false-positive result owing to a nonspecific passive hemagglutination reaction was estimated to be 0.17% for either cell type.

Reactivity of nonsensitized control erythrocytes in rubella passive hemagglutination assays